Maisonneuve-Rosemont Hospital Université de Montréal

Promising research

HSC transplantation-related areas of research

A great deal of exciting research is currently being conducted in the area of hematopoietic stem cell transplantation. At Maisonneuve-Rosemont Hospital’s Research Centre, within which the Centre of Excellence for Cellular Therapy will soon open, work is actively going on to resolve various problems related to stem cell transplantation.

Among such problems are:

At issue is the manipulation of transplants in order to maximize their benefits.

But how, exactly, is a transplant "manipulated"? It should be realized that a transplant is made up of a number of components: hematopoietic stem cells, of course, but also white blood cells (T and B lymphocytes, macrophages, etc.) and other types, like mesenchymal cells.

Each of these cells has an important role to play, whether in the recipient body’s acceptance of the transplant, the transformation of stem cells into mature blood cells, the eradication of tumour cells, or in overall immune response.

The major discoveries made at MRH in respect to these problems have enabled improvement in the effectiveness of HSC transplants.

And the research continues…